Entry - *606138 - CELL GROWTH REGULATOR WITH RING FINGER DOMAIN 1; CGRRF1 - OMIM

 
 
* 606138

CELL GROWTH REGULATOR WITH RING FINGER DOMAIN 1; CGRRF1


Alternative titles; symbols

CELL GROWTH REGULATORY GENE 19; CGR19


HGNC Approved Gene Symbol: CGRRF1

Cytogenetic location: 14q22.2   Genomic coordinates (GRCh38) : 14:54,509,906-54,539,292 (from NCBI)


TEXT

▼ Cloning and Expression

Using differential RT-PCR analysis of rat embryo fibroblast cells containing a temperature-sensitive p53 (191170) allele, Madden et al. (1996) isolated several transcripts upregulated specifically in cells harboring functional p53 protein, including 2 novel transcripts that the authors termed cell growth regulatory genes 11 (CGR11; 606137) and 19 (CGR19). The full-length CGR19 cDNA obtained from a human fetal brain cDNA library encodes a 332-amino acid protein with a putative zinc-binding C3HC4 RING finger domain at the C terminus. The human and rat CGR19 proteins share 85% overall sequence identity. Northern blot analysis of rat tissues demonstrated ubiquitous expression of CGR19, with highest levels in testis. Transfection assay experiments demonstrated that CGR19 is able to inhibit growth in several cell lines.


▼ Mapping

Stumpf (2023) mapped the CGRRF1 gene to chromosome 14q22.2 based on an alignment of the CGRRF1 sequence (GenBank BC015063) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., Beaudry, G. A. Induction of cell growth regulatory genes by p53. Cancer Res. 56: 5384-5390, 1996. [PubMed: 8968090, related citations]

  2. Stumpf, A. M. Personal Communication. Baltimore, Md. 12/05/2023.


Contributors:
Anne M. Stumpf - updated : 12/05/2023
Creation Date:
Carol A. Bocchini : 7/23/2001
Edit History:
alopez : 12/05/2023
alopez : 04/07/2009
mcapotos : 7/24/2001
carol : 7/23/2001
carol : 7/23/2001

* 606138

CELL GROWTH REGULATOR WITH RING FINGER DOMAIN 1; CGRRF1


Alternative titles; symbols

CELL GROWTH REGULATORY GENE 19; CGR19


HGNC Approved Gene Symbol: CGRRF1

Cytogenetic location: 14q22.2   Genomic coordinates (GRCh38) : 14:54,509,906-54,539,292 (from NCBI)


TEXT

Cloning and Expression

Using differential RT-PCR analysis of rat embryo fibroblast cells containing a temperature-sensitive p53 (191170) allele, Madden et al. (1996) isolated several transcripts upregulated specifically in cells harboring functional p53 protein, including 2 novel transcripts that the authors termed cell growth regulatory genes 11 (CGR11; 606137) and 19 (CGR19). The full-length CGR19 cDNA obtained from a human fetal brain cDNA library encodes a 332-amino acid protein with a putative zinc-binding C3HC4 RING finger domain at the C terminus. The human and rat CGR19 proteins share 85% overall sequence identity. Northern blot analysis of rat tissues demonstrated ubiquitous expression of CGR19, with highest levels in testis. Transfection assay experiments demonstrated that CGR19 is able to inhibit growth in several cell lines.


Mapping

Stumpf (2023) mapped the CGRRF1 gene to chromosome 14q22.2 based on an alignment of the CGRRF1 sequence (GenBank BC015063) with the genomic sequence (GRCh38).

REFERENCES

  1. Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., Beaudry, G. A. Induction of cell growth regulatory genes by p53. Cancer Res. 56: 5384-5390, 1996. [PubMed: 8968090]

  2. Stumpf, A. M. Personal Communication. Baltimore, Md. 12/05/2023.


Contributors:
Anne M. Stumpf - updated : 12/05/2023

Creation Date:
Carol A. Bocchini : 7/23/2001

Edit History:
alopez : 12/05/2023
alopez : 04/07/2009
mcapotos : 7/24/2001
carol : 7/23/2001
carol : 7/23/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024