HGNC Approved Gene Symbol: RANBP17
Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38) : 5:170,862,018-171,300,015 (from NCBI)
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see 600685 and 602738. The small GTPase RAN (601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.
In the course of cloning genes at the breakpoint of t(5;14)(q33-q34;q11), a recurring translocation in acute lymphoblastic leukemia, Koch et al. (2000) isolated and characterized 2 novel members of the importin-beta superfamily of nuclear transport receptors: RANBP17, located at 5q34, and RANBP16 (606140), located on chromosome 8. They also cloned the mouse Ranbp16 and Ranbp17 homologs. The human and mouse RANBP17 cDNAs encode 1,088-amino acid proteins containing an importin-beta N-terminal domain which is important for the binding of Ran protein. Human RANBP16 and RANBP17 share 66% amino acid sequence identity. Northern blot analysis showed ubiquitous expression of RANBP16, but restricted expression of RANBP17. Two RANBP17 transcripts of approximately 2.5 and 4.5 kb were strongly expressed in human testis, whereas 3 transcripts of approximately 4.5, 7.5, and 10 kb were moderately expressed in pancreas and weakly expressed in heart, placenta, lung, liver, thyroid, spinal cord, trachea, and adrenal gland. Murine Ranbp17 also showed a restricted expression pattern with a marked signal in testis. Both RANBP16 and RANBP17 are predominantly nuclear proteins.
Koch, P., Bohlmann, I., Schafer, M., Hansen-Hagge, T. E., Kiyoi, H., Wilda, M., Hameister, H., Bartram, C. R., Janssen, J. W. G. Identification of a novel putative Ran-binding protein and its close homologue. Biochem. Biophys. Res. Commun. 278: 241-249, 2000. [PubMed: 11071879] [Full Text: https://doi.org/10.1006/bbrc.2000.3788]