HGNC Approved Gene Symbol: BIN3
Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38) : 8:22,620,418-22,669,121 (from NCBI)
Bin/amphiphysin/Rvs (BAR) domain adaptor proteins, such as BIN3, are named for their unique N-terminal region and appear to integrate signal transduction pathways that regulate membrane dynamics, F-actin cytoskeleton, and nuclear processes.
Using yeast Rvs161 as a probe in an EST database search, Routhier et al. (2001) identified a cDNA encoding BIN3. The deduced 253-amino acid protein, like its yeast counterpart, is composed solely of a BAR domain. Northern blot analysis revealed expression of a 2.2-kb BIN3 transcript in all adult and embryonic tissues tested except brain. In contrast, the BAR family members AMPH (600418) and BIN2 (605936) are expressed primarily in brain and hematopoietic tissues, respectively. Like BIN3, BIN1 (601248) is widely expressed; however, BIN1 expression is decreased in tumor cells, while BIN3 expression is not.
By functional analysis, Routhier et al. (2001) showed that BIN3 rescued the actin localization defects of hob3+, a mutant S. pombe homolog of BIN3, but not the osmosensitivity of mutant Rvs161. These results suggested that some, but not all, roles of BIN3 have been preserved during evolution.
Stumpf (2023) mapped the BIN3 gene to chromosome 8p21.3 based on an alignment of the BIN3 sequence (GenBank BC009824) with the genomic sequence (GRCh38).
Routhier, E. L., Burn, T. C., Abbaszade, I., Summers, M., Albright, C. F., Prendergast, G. C. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. J. Biol. Chem. 276: 21670-21677, 2001. [PubMed: 11274158] [Full Text: https://doi.org/10.1074/jbc.M101096200]
Stumpf, A. M. Personal Communication. Baltimore, Md. 12/18/2023.