Entry - *606402 - GASTROKINE 1; GKN1 - OMIM

 
 
* 606402

GASTROKINE 1; GKN1


Alternative titles; symbols

CA11 GENE
BRICHOS DOMAIN-CONTAINING 1; BRICD1
ANTRUM MUCOSA PROTEIN, 18-KD; AMP18
FOVEOLIN; FOV


HGNC Approved Gene Symbol: GKN1

Cytogenetic location: 2p13.3   Genomic coordinates (GRCh38) : 2:68,974,636-68,980,976 (from NCBI)


TEXT

▼ Cloning and Expression

Using differential display of normal and cancerous gastric tissue, followed by 5-prime RACE, Yoshikawa et al. (2000) identified cDNAs encoding CA11 and CAPN9 (606401). The deduced 199-amino acid CA11 protein contains an asn-rich region. Northern blot analysis revealed expression of an approximately 1.1-kb CA11 transcript predominantly in stomach; no expression was detected in cancer tissue or gastric cancer cell lines.


▼ Mapping

Stumpf (2024) mapped the GKN1 gene to chromosome 2p13.3 based on an alignment of the GKN1 sequence (GenBank AY139184) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Stumpf, A. M. Personal Communication. Baltimore, Md. 08/16/2024.

  2. Yoshikawa, Y., Mukai, H., Hino, F., Asada, K., Kato, I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn. J. Cancer Res. 91: 459-463, 2000. [PubMed: 10835488, related citations] [Full Text]


Contributors:
Anne M. Stumpf - updated : 08/16/2024
Creation Date:
Paul J. Converse : 10/19/2001
Edit History:
alopez : 08/16/2024
alopez : 06/27/2005
mgross : 10/19/2001

* 606402

GASTROKINE 1; GKN1


Alternative titles; symbols

CA11 GENE
BRICHOS DOMAIN-CONTAINING 1; BRICD1
ANTRUM MUCOSA PROTEIN, 18-KD; AMP18
FOVEOLIN; FOV


HGNC Approved Gene Symbol: GKN1

Cytogenetic location: 2p13.3   Genomic coordinates (GRCh38) : 2:68,974,636-68,980,976 (from NCBI)


TEXT

Cloning and Expression

Using differential display of normal and cancerous gastric tissue, followed by 5-prime RACE, Yoshikawa et al. (2000) identified cDNAs encoding CA11 and CAPN9 (606401). The deduced 199-amino acid CA11 protein contains an asn-rich region. Northern blot analysis revealed expression of an approximately 1.1-kb CA11 transcript predominantly in stomach; no expression was detected in cancer tissue or gastric cancer cell lines.


Mapping

Stumpf (2024) mapped the GKN1 gene to chromosome 2p13.3 based on an alignment of the GKN1 sequence (GenBank AY139184) with the genomic sequence (GRCh38).

REFERENCES

  1. Stumpf, A. M. Personal Communication. Baltimore, Md. 08/16/2024.

  2. Yoshikawa, Y., Mukai, H., Hino, F., Asada, K., Kato, I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn. J. Cancer Res. 91: 459-463, 2000. [PubMed: 10835488] [Full Text: https://doi.org/10.1111/j.1349-7006.2000.tb00967.x]


Contributors:
Anne M. Stumpf - updated : 08/16/2024

Creation Date:
Paul J. Converse : 10/19/2001

Edit History:
alopez : 08/16/2024
alopez : 06/27/2005
mgross : 10/19/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024