Entry - *606413 - INSULIN-LIKE 5; INSL5 - OMIM

 
 
* 606413

INSULIN-LIKE 5; INSL5


HGNC Approved Gene Symbol: INSL5

Cytogenetic location: 1p31.3   Genomic coordinates (GRCh38) : 1:66,797,740-66,801,276 (from NCBI)


TEXT

▼ Description

Members of the insulin gene superfamily, such as INSL5, regulate cell growth, metabolism, and tissue-specific functions. Members of this family are characterized by a signal peptide, a B chain, a connecting C chain, and an A chain (summary by Conklin et al., 1999).


▼ Cloning and Expression

By EST database searching for sequences related to relaxin (RLN1; 179730), Conklin et al. (1999) identified a cDNA encoding INSL5, also designated ZINS3. The deduced 135-amino acid protein, which shares 59% and 40% sequence identity with mouse Insl5 and human RLN1, respectively, has a dibasic cleavage site between the B and C chains. Northern blot analysis revealed expression of an approximately 1.0-kb transcript in uterus, rectum, and colon.


▼ Mapping

By radiation hybrid analysis and the use of surrounding markers, Conklin et al. (1999) mapped the INSL5 gene to chromosome 1p31.1-p22.3.


▼ REFERENCES

  1. Conklin, D., Lofton-Day, C. E., Haldeman, B. A., Ching, A., Whitmore, T. E., Lok, S., Jaspers, S. Identification of INSL5, a new member of the insulin superfamily. Genomics 60: 50-56, 1999. [PubMed: 10458910, related citations] [Full Text]


Creation Date:
Paul J. Converse : 10/25/2001
Edit History:
carol : 11/19/2021
cwells : 10/26/2001
cwells : 10/25/2001

* 606413

INSULIN-LIKE 5; INSL5


HGNC Approved Gene Symbol: INSL5

Cytogenetic location: 1p31.3   Genomic coordinates (GRCh38) : 1:66,797,740-66,801,276 (from NCBI)


TEXT

Description

Members of the insulin gene superfamily, such as INSL5, regulate cell growth, metabolism, and tissue-specific functions. Members of this family are characterized by a signal peptide, a B chain, a connecting C chain, and an A chain (summary by Conklin et al., 1999).


Cloning and Expression

By EST database searching for sequences related to relaxin (RLN1; 179730), Conklin et al. (1999) identified a cDNA encoding INSL5, also designated ZINS3. The deduced 135-amino acid protein, which shares 59% and 40% sequence identity with mouse Insl5 and human RLN1, respectively, has a dibasic cleavage site between the B and C chains. Northern blot analysis revealed expression of an approximately 1.0-kb transcript in uterus, rectum, and colon.


Mapping

By radiation hybrid analysis and the use of surrounding markers, Conklin et al. (1999) mapped the INSL5 gene to chromosome 1p31.1-p22.3.


REFERENCES

  1. Conklin, D., Lofton-Day, C. E., Haldeman, B. A., Ching, A., Whitmore, T. E., Lok, S., Jaspers, S. Identification of INSL5, a new member of the insulin superfamily. Genomics 60: 50-56, 1999. [PubMed: 10458910] [Full Text: https://doi.org/10.1006/geno.1999.5899]


Creation Date:
Paul J. Converse : 10/25/2001

Edit History:
carol : 11/19/2021
cwells : 10/26/2001
cwells : 10/25/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024