Entry - *606427 - ZINC FINGER PROTEIN 320; ZNF320 - OMIM

 
 
* 606427

ZINC FINGER PROTEIN 320; ZNF320


HGNC Approved Gene Symbol: ZNF320

Cytogenetic location: 19q13.41   Genomic coordinates (GRCh38) : 19:52,859,491-52,904,320 (from NCBI)


TEXT

▼ Description

ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.

▼ Cloning and Expression

Allelic deletions in 10q25-q26 and 19q13.3-q13.4 are common genetic alterations in glial tumors. Chernova et al. (2001) identified a balanced t(10;19) reciprocal translocation in a glioblastoma cell line (A172) that involved both critical regions on chromosomes 10 and 19. By positional cloning of the translocation breakpoint, they identified a novel WD-repeat gene on chromosome 10, which they designated WDR11 (606417), and a novel member of the Kruppel-like zinc finger family, which they designated ZNF320, on chromosome 19. They identified the 2 last exons of the ZNF320 gene, one encoding the KRAB-domain and the other encoding a zinc finger domain. Northern blot analysis detected a single, approximately 4.5-kb transcript at highest levels in placenta, pancreas, kidney, and heart and at lower levels in liver, skeletal muscle, and brain. RT-PCR analysis demonstrated expression of ZNF320 in several cancer cell lines tested, including glioblastoma cell line A172. Chernova et al. (2001) determined that the translocation resulted in deletion of exon 5 and fusion of intron 4 of WDR11 to the 3-prime untranslated region of ZNF320. Because of the presence of unrearranged chromosome 19 in the A172 cells, Chernova et al. (2001) could not determine whether the t(10;19) translocation affected the expression of the altered ZNF320 gene.


▼ Mapping

By positional cloning, Chernova et al. (2001) mapped the ZNF320 gene to chromosome 19q13.3-q13.4.


▼ REFERENCES

  1. Chernova, O. B., Hunyadi, A., Malaj, E., Pan, H., Crooks, C., Roe, B., Cowell, J. K. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Oncogene 20: 5378-5392, 2001. [PubMed: 11536051, related citations] [Full Text]


Creation Date:
Carol A. Bocchini : 10/31/2001
Edit History:
alopez : 09/29/2009
terry : 10/31/2001
carol : 10/31/2001

* 606427

ZINC FINGER PROTEIN 320; ZNF320


HGNC Approved Gene Symbol: ZNF320

Cytogenetic location: 19q13.41   Genomic coordinates (GRCh38) : 19:52,859,491-52,904,320 (from NCBI)


TEXT

Description

ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.

Cloning and Expression

Allelic deletions in 10q25-q26 and 19q13.3-q13.4 are common genetic alterations in glial tumors. Chernova et al. (2001) identified a balanced t(10;19) reciprocal translocation in a glioblastoma cell line (A172) that involved both critical regions on chromosomes 10 and 19. By positional cloning of the translocation breakpoint, they identified a novel WD-repeat gene on chromosome 10, which they designated WDR11 (606417), and a novel member of the Kruppel-like zinc finger family, which they designated ZNF320, on chromosome 19. They identified the 2 last exons of the ZNF320 gene, one encoding the KRAB-domain and the other encoding a zinc finger domain. Northern blot analysis detected a single, approximately 4.5-kb transcript at highest levels in placenta, pancreas, kidney, and heart and at lower levels in liver, skeletal muscle, and brain. RT-PCR analysis demonstrated expression of ZNF320 in several cancer cell lines tested, including glioblastoma cell line A172. Chernova et al. (2001) determined that the translocation resulted in deletion of exon 5 and fusion of intron 4 of WDR11 to the 3-prime untranslated region of ZNF320. Because of the presence of unrearranged chromosome 19 in the A172 cells, Chernova et al. (2001) could not determine whether the t(10;19) translocation affected the expression of the altered ZNF320 gene.


Mapping

By positional cloning, Chernova et al. (2001) mapped the ZNF320 gene to chromosome 19q13.3-q13.4.


REFERENCES

  1. Chernova, O. B., Hunyadi, A., Malaj, E., Pan, H., Crooks, C., Roe, B., Cowell, J. K. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Oncogene 20: 5378-5392, 2001. [PubMed: 11536051] [Full Text: https://doi.org/10.1038/sj.onc.1204694]


Creation Date:
Carol A. Bocchini : 10/31/2001

Edit History:
alopez : 09/29/2009
terry : 10/31/2001
carol : 10/31/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024