Alternative titles; symbols
HGNC Approved Gene Symbol: ZMAT3
Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38) : 3:179,017,223-179,072,513 (from NCBI)
Varmeh-Ziaie et al. (1997) identified a novel p53-induced mouse gene, designated wig1, that encodes a 290-amino acid zinc finger protein. In response to p53 activation, wig1 mRNA levels were induced with similar kinetics as p21, suggesting that wig1 is a direct target of p53. Varmeh-Ziaie et al. (1997) found that wig1 mRNA was expressed at very low levels under normal conditions in most tissues tested, except brain and testis in which higher levels were expressed.
Hellborg et al. (2001) identified and characterized the human homolog of mouse wig1. The 288-amino acid protein is 87% identical to the mouse protein and contains 3 zinc finger domains and a putative nuclear localization signal. WIG1 mRNA and 32-kD protein were induced following activation of wildtype p53 expression in a Burkitt lymphoma cell line. The induction occurred also in MCF7 cells following treatment with the DNA-damaging agent mitomycin C. Northern blot analysis revealed low level but ubiquitous expression of 10.0- and 7.2-kb WIG1 transcripts. Fluorescence microscopy localized WIG1 to the nucleus. Overexpression of human WIG1 inhibited cell growth.
By fluorescence in situ hybridization, Hellborg et al. (2001) mapped the WIG1 gene to chromosome 3q26.3-q27.
Hellborg, F., Qian, W., Mendez-Vidal, C., Asker, C., Kost-Alimova, M., Wilhelm, M., Imreh, S., Wiman, K. G. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. Oncogene 20: 5466-5474, 2001. [PubMed: 11571644] [Full Text: https://doi.org/10.1038/sj.onc.1204722]
Varmeh-Ziaie, S., Okan, I., Wang, Y., Magnusson, K. P., Warthoe, P., Strauss, M., Wiman, K. G. Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene 15: 2699-2704, 1997. [PubMed: 9400996] [Full Text: https://doi.org/10.1038/sj.onc.1201454]