Entry - *606957 - ZINC FINGER PROTEIN 257; ZNF257 - OMIM

 
 
* 606957

ZINC FINGER PROTEIN 257; ZNF257


HGNC Approved Gene Symbol: ZNF257

Cytogenetic location: 19p12   Genomic coordinates (GRCh38) : 19:22,052,484-22,091,480 (from NCBI)


TEXT

▼ Cloning and Expression

Using PCR primers based on conserved sequences of Kruppel-like genes to screen a bone marrow cDNA library, followed by database searching and 3-prime and 5-prime RACE, Han et al. (1999) isolated cDNAs encoding several zinc finger proteins, ZNF257. The deduced 535-amino acid ZNF257 protein contains 4 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal Kruppel-associated box (KRAB). In the hematopoietic system, RT-PCR analysis detected selective expression restricted to myelomonocytic cell lines.


▼ Mapping

Using FISH, Han et al. (1999) mapped the ZNF257 gene to chromosome 19q13, where the ZNF253 (606954) and ZNF254 (604768) genes also map.


▼ REFERENCES

  1. Han, Z.-G., Zhang, Q.-H., Ye, M., Kan, L.-X., Gu, B.-W., He, K.-L., Shi, S.-L., Zhou, J., Fu, G., Mao, M., Chen, S.-J., Yu, L., Chen, Z. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. J. Biol. Chem. 274: 35741-35748, 1999. [PubMed: 10585455, related citations] [Full Text]


Creation Date:
Paul J. Converse : 5/21/2002
Edit History:
mgross : 05/21/2002

* 606957

ZINC FINGER PROTEIN 257; ZNF257


HGNC Approved Gene Symbol: ZNF257

Cytogenetic location: 19p12   Genomic coordinates (GRCh38) : 19:22,052,484-22,091,480 (from NCBI)


TEXT

Cloning and Expression

Using PCR primers based on conserved sequences of Kruppel-like genes to screen a bone marrow cDNA library, followed by database searching and 3-prime and 5-prime RACE, Han et al. (1999) isolated cDNAs encoding several zinc finger proteins, ZNF257. The deduced 535-amino acid ZNF257 protein contains 4 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal Kruppel-associated box (KRAB). In the hematopoietic system, RT-PCR analysis detected selective expression restricted to myelomonocytic cell lines.


Mapping

Using FISH, Han et al. (1999) mapped the ZNF257 gene to chromosome 19q13, where the ZNF253 (606954) and ZNF254 (604768) genes also map.


REFERENCES

  1. Han, Z.-G., Zhang, Q.-H., Ye, M., Kan, L.-X., Gu, B.-W., He, K.-L., Shi, S.-L., Zhou, J., Fu, G., Mao, M., Chen, S.-J., Yu, L., Chen, Z. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. J. Biol. Chem. 274: 35741-35748, 1999. [PubMed: 10585455] [Full Text: https://doi.org/10.1074/jbc.274.50.35741]


Creation Date:
Paul J. Converse : 5/21/2002

Edit History:
mgross : 05/21/2002



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024