HGNC Approved Gene Symbol: RASSF3
Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38) : 12:64,506,964-64,697,564 (from NCBI)
The RAS oncogene (190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.
By database searching for sequences similar to RASSF1 (605082), a putative tumor suppressor, Tommasi et al. (2002) identified mouse and human RASSF3. The deduced 247-amino acid human protein has a C-terminal RA domain that is approximately 45% identical to that of RASSF1 and mouse Nore1 (607020). Northern blot analysis detected a 3.8-kb transcript in all normal tissues and cancer cell lines tested; some of the cancer cell lines expressed shorter transcripts as well. Northern blot and 5-prime RACE analyses failed to identify any splice variants.
By genomic sequence analysis, Tommasi et al. (2002) determined that the RASSF3 gene contains 5 exons.
By genomic sequence analysis, Tommasi et al. (2002) mapped the RASSF3 gene to chromosome 12q14.1.
Tommasi, S., Dammann, R., Jin, S.-G., Zhang, X., Avruch, J., Pfeifer, G. P. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene 21: 2713-2720, 2002. [PubMed: 11965544] [Full Text: https://doi.org/10.1038/sj.onc.1205365]