Entry - *607171 - CYSTEINE-RICH PROTEIN WITH EGF-LIKE DOMAINS 2 - OMIM

 
 
* 607171

CYSTEINE-RICH PROTEIN WITH EGF-LIKE DOMAINS 2


Alternative titles; symbols

CRELD2


HGNC Approved Gene Symbol: CRELD2

Cytogenetic location: 22q13.33   Genomic coordinates (GRCh38) : 22:49,918,634-49,927,537 (from NCBI)


▼ TEXT

For background information on CRELD proteins, see CRELD1 (607170).

▼ Cloning and Expression

Rupp et al. (2002) identified CRELD2 by searching a sequence database using CRELD1 as the query. Like CRELD1, with which it shares 38% amino acid identity, the deduced 321-amino acid CRELD2 protein contains EGF-like repeats and a highly conserved domain rich in glutamic acid and tryptophan (WE domain). The major distinction between CRELD1 and CRELD2 is that CRELD1 has 2 type III transmembrane domains in its C terminus, while CRELD2 has none. CRELD2 shares 67% and 69% amino acid identity with its Chinese hamster and mouse homologs, respectively.


▼ Mapping

By genomic sequence analysis, Rupp et al. (2002) mapped the CRELD2 gene to chromosome 22p13.


▼ REFERENCES

  1. Rupp, P. A., Fouad, G. T., Egelston, C. A., Reifsteck, C. A., Olson, S. B., Knosp, W. M., Glanville, R. W., Thornburg, K. L., Robinson, S. W., Maslen, C. L. Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. Gene 293: 47-57, 2002. [PubMed: 12137942, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 8/27/2002
Edit History:
mgross : 08/27/2002

* 607171

CYSTEINE-RICH PROTEIN WITH EGF-LIKE DOMAINS 2


Alternative titles; symbols

CRELD2


HGNC Approved Gene Symbol: CRELD2

Cytogenetic location: 22q13.33   Genomic coordinates (GRCh38) : 22:49,918,634-49,927,537 (from NCBI)


TEXT

For background information on CRELD proteins, see CRELD1 (607170).

Cloning and Expression

Rupp et al. (2002) identified CRELD2 by searching a sequence database using CRELD1 as the query. Like CRELD1, with which it shares 38% amino acid identity, the deduced 321-amino acid CRELD2 protein contains EGF-like repeats and a highly conserved domain rich in glutamic acid and tryptophan (WE domain). The major distinction between CRELD1 and CRELD2 is that CRELD1 has 2 type III transmembrane domains in its C terminus, while CRELD2 has none. CRELD2 shares 67% and 69% amino acid identity with its Chinese hamster and mouse homologs, respectively.


Mapping

By genomic sequence analysis, Rupp et al. (2002) mapped the CRELD2 gene to chromosome 22p13.


REFERENCES

  1. Rupp, P. A., Fouad, G. T., Egelston, C. A., Reifsteck, C. A., Olson, S. B., Knosp, W. M., Glanville, R. W., Thornburg, K. L., Robinson, S. W., Maslen, C. L. Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. Gene 293: 47-57, 2002. [PubMed: 12137942] [Full Text: https://doi.org/10.1016/s0378-1119(02)00696-0]


Creation Date:
Patricia A. Hartz : 8/27/2002

Edit History:
mgross : 08/27/2002



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024