Alternative titles; symbols
HGNC Approved Gene Symbol: LGALS14
Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38) : 19:39,704,481-39,709,444 (from NCBI)
PPL13 belongs to a family of proteins called galectins. Galectins are lectins containing 1 or 2 carbohydrate recognition domains (CRDs), and they show calcium-independent binding of beta-galactoside.
Yang et al. (2002) cloned PPL13 from a fetal brain cDNA library. The deduced 139-amino acid protein has a calculated molecular mass of 16.1 kD. PPL13 contains a single CRD domain and several putative phosphorylation sites, but no signal peptide or targeting signals. The PPL13 protein shares 78%, 67%, and 54% amino acid identity with the PP13, galectin-10 (CLC; 153310), and sheep ovgal11 proteins, respectively. Northern blot analysis revealed a 1-kb transcript expressed only in placenta. Yang et al. (2002) noted that ESTs for PPL13 had been purified from aorta, ovary, fetal brain, and fetal spleen/liver cDNA libraries. Transfection of fluorescence-tagged PPL13 into COS-7 cells resulted in protein localization predominantly in the nucleus.
Yang et al. (2002) determined that the PPL13 gene contains 4 exons.
By genomic sequence analysis, Yang et al. (2002) mapped the PPL13 gene to chromosome 19q13.2.
Yang, Q.-S., Ying, K., Yuan, H.-L., Chen, J.-Z., Meng, X.-F., Wang, Z., Xie, Y., Mao, Y.-M. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta. Biochim. Biophys. Acta 1574: 407-411, 2002. [PubMed: 11997112] [Full Text: https://doi.org/10.1016/s0167-4781(01)00319-0]