HGNC Approved Gene Symbol: SSBP4
Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38) : 19:18,402,725-18,434,562 (from NCBI)
By EST database searching with the SSBP2 (607389) sequence as probe, Castro et al. (2002) identified 2 additional members of the SSBP gene family, SSBP3 (607390) and SSBP4. All 3 SSBP genes share homology with the chicken gene CSDP, which encodes a protein that binds single-stranded pyrimidine-rich mirror-repeat elements with high specificity. The deduced 364-amino acid SSBP4 protein shares 73% and 72% sequence identity with human SSBP2 and SSBP3, respectively. SSBP family members share a highly conserved N terminus followed by a glycine- and proline-rich domain.
Castro et al. (2002) determined that the SSBP2, SSBP3, and SSBP4 genes all contain 17 exons and have identical intron/exon boundaries, suggesting duplication from a common ancestral gene. They also identified alternative splicing and additional internal exons for all 3 genes, suggesting the existence of multiple isoforms for each protein. The SSBP4 gene spans less than 25 kb.
By genomic sequence analysis, Castro et al. (2002) mapped the SSBP4 gene to chromosome 19p13.1, between markers D19S899 and D19S407.
Castro, P., Liang, H., Liang, J. C., Nagarajan, L. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. Genomics 80: 78-85, 2002. [PubMed: 12079286] [Full Text: https://doi.org/10.1006/geno.2002.6805]