Entry - *607744 - FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; FRS3 - OMIM

 
 
* 607744

FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; FRS3


Alternative titles; symbols

FGFR SUBSTRATE 3
FRS2-BETA; FRS2B
SUC1-ASSOCIATED NEUROTROPHIC FACTOR TARGET 2; SNT2


HGNC Approved Gene Symbol: FRS3

Cytogenetic location: 6p21.1   Genomic coordinates (GRCh38) : 6:41,770,176-41,779,900 (from NCBI)


TEXT

▼ Cloning and Expression

Xu et al. (1998) cloned and characterized SNT2. The deduced 492-amino acid protein is 49% identical to SNT1 (607743). Both SNTs contain a myristylation sequence, a phosphotyrosine-binding (PTB) domain, and several tyrosine-containing motifs that govern GRB2 (108355) and SHP2 (176876) recruitment.


▼ Gene Function

Using yeast 2-hybrid interaction assays, Xu et al. (1998) showed that SNT1 and SNT2 directly bind to FGFR1 (136350). A juxtamembrane segment of FGFR1 and the PTB domain of the SNTs were both necessary and sufficient for interaction in yeast and in vitro, and FGFR-mediated SNT tyrosine phosphorylation in vivo required these segments.


▼ REFERENCES

  1. Xu, H., Lee, K. W., Goldfarb, M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J. Biol. Chem. 273: 17987-17990, 1998. [PubMed: 9660748, related citations] [Full Text]


Creation Date:
Stylianos E. Antonarakis : 5/1/2003
Edit History:
carol : 08/27/2014
mgross : 5/1/2003
mgross : 5/1/2003

* 607744

FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; FRS3


Alternative titles; symbols

FGFR SUBSTRATE 3
FRS2-BETA; FRS2B
SUC1-ASSOCIATED NEUROTROPHIC FACTOR TARGET 2; SNT2


HGNC Approved Gene Symbol: FRS3

Cytogenetic location: 6p21.1   Genomic coordinates (GRCh38) : 6:41,770,176-41,779,900 (from NCBI)


TEXT

Cloning and Expression

Xu et al. (1998) cloned and characterized SNT2. The deduced 492-amino acid protein is 49% identical to SNT1 (607743). Both SNTs contain a myristylation sequence, a phosphotyrosine-binding (PTB) domain, and several tyrosine-containing motifs that govern GRB2 (108355) and SHP2 (176876) recruitment.


Gene Function

Using yeast 2-hybrid interaction assays, Xu et al. (1998) showed that SNT1 and SNT2 directly bind to FGFR1 (136350). A juxtamembrane segment of FGFR1 and the PTB domain of the SNTs were both necessary and sufficient for interaction in yeast and in vitro, and FGFR-mediated SNT tyrosine phosphorylation in vivo required these segments.


REFERENCES

  1. Xu, H., Lee, K. W., Goldfarb, M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J. Biol. Chem. 273: 17987-17990, 1998. [PubMed: 9660748] [Full Text: https://doi.org/10.1074/jbc.273.29.17987]


Creation Date:
Stylianos E. Antonarakis : 5/1/2003

Edit History:
carol : 08/27/2014
mgross : 5/1/2003
mgross : 5/1/2003



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024