HGNC Approved Gene Symbol: GPR135
Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38) : 14:59,452,783-59,465,380 (from NCBI)
GPR135 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).
By database searching with conserved sequences of the rhodopsin family of GPRs as query, Fredriksson et al. (2003) identified EST and cDNA clones encoding several novel GPRs, including GPR135. The deduced 494-amino acid protein contains the characteristic 7 transmembrane (TM) domains, a DRY motif in the intracellular side of TM3, and an NSxxNPxxY motif in TM7. GPR135 shares 81% and 96% sequence identity with mouse and rat Gpr135 proteins, respectively. It also shares similarity with bioamine receptors. Analysis of EST sequences indicated expression of GPR135 in a variety of tissues including eye, brain, cervix, stomach, and testis.
By sequence analysis, Fredriksson et al. (2003) mapped the GPR135 gene to chromosome 14q23.1. They mapped the mouse Gpr135 gene to chromosome 12.
Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098] [Full Text: https://doi.org/10.1016/s0014-5793(03)01196-7]