Alternative titles; symbols
HGNC Approved Gene Symbol: MRO
Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38) : 18:50,795,130-50,825,380 (from NCBI)
By sequencing a region of chromosome 18 that contains a segment deleted in the Ma29 lung cancer cell line, followed by screening a brain cDNA library, Yanaihara et al. (2001) cloned B29. B29 is located outside the Ma29 deletion. The deduced B29 protein contains 248 amino acids. Yanaihara et al. (2001) also identified 3 minor isoforms that differ in the reading frame utilized and in the presence or absence of exon 3 and/or exon 6. Expression levels were below the limit of detection for Northern blot analysis, but RT-PCR found near ubiquitous expression.
Yanaihara et al. (2001) determined that the B29 gene contains 8 exons.
By genomic sequence analysis, Yanaihara et al. (2001) mapped the B29 gene to chromosome 18q21.
Yanaihara, N., Kohno, T., Takakura, S., Takei, K., Otsuka, A., Sunaga, N., Takahashi, M., Yamazaki, M., Tashiro, H., Fukuzumi, Y., Fujimori, Y., Hagiwara, K., Tanaka, T., Yokota, J. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. Genomics 72: 169-179, 2001. [PubMed: 11401430] [Full Text: https://doi.org/10.1006/geno.2000.6454]