Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF213
Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38) : 16:3,135,029-3,142,804 (from NCBI)
C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.
By sequencing candidate genes within the FMF locus (249100) on chromosome 16, PCR of fetal brain, fetal liver, and lymph node cDNA libraries, and screening a peripheral blood leukocyte cDNA library, Chen et al. (1999) cloned ZNF213. The deduced 424-amino acid protein contains an N-terminal leucine-rich domain, followed by a Kruppel-associated box and C-terminal zinc fingers. Northern blot analysis detected a 3.8-kb transcript in all tissues examined. Highest expression was detected in testis, followed by ovary, small intestine, prostate, spleen, thymus, mucosal lining of colon, and peripheral blood lymphocytes.
Chen et al. (1999) determined that the ZNF213 gene contains 7 exons and spans about 8.0 kb. The 5-prime untranslated region is GC rich.
By genomic sequence analysis, Bernot et al. (1998) mapped the ZNF213 gene, which they designated CR53, to chromosome 16p13.3. The gene is oriented with its 5-prime end toward the telomere. Chen et al. (1999) determined that the ZNF213 gene lies within a ZNF gene cluster that includes ZNF263 (604191) and ZNF174 (603900).
Bernot, A., Heilig, R., Clepet, C., Smaoui, N., Da Silva, C., Petit, J.-L., Devaud, C., Chiannilkulchai, N., Fizames, C., Samson, D., Cruaud, C., Caloustian, C., Gyapay, G., Delpech, M., Weissenbach, J. A transcriptional map of the FMF region. Genomics 50: 147-160, 1998. [PubMed: 9653642] [Full Text: https://doi.org/10.1006/geno.1998.5313]
Chen, X., Hamon, M., Deng, Z., Centola, M., Sood, R., Taylor, K., Kastner, D. L., Fischel-Ghodsian, N. Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. Biochim. Biophys. Acta 1444: 218-230, 1999. [PubMed: 10023065] [Full Text: https://doi.org/10.1016/s0167-4781(98)00273-5]