Entry - *608534 - ACTIN-RELATED PROTEIN M1 - OMIM

 
 
* 608534

ACTIN-RELATED PROTEIN M1


Alternative titles; symbols

ARPM1


HGNC Approved Gene Symbol: ACTRT3

Cytogenetic location: 3q26.2   Genomic coordinates (GRCh38) : 3:169,766,921-169,769,561 (from NCBI)


TEXT

▼ Cloning and Expression

By searching an EST database for actin-related proteins, Harata et al. (2001) identified ARPM1. The deduced 372-amino acid protein contains an actin-like ATP/ADP-binding pocket and 2 nuclear export signals. However, residues likely to be involved in actin-actin and actin-myosin (see 160730) contacts are not well conserved in ARPM1. ARPM1 shares 50% amino acid identity with beta-actin (102630) and 46% identity with ARPM2 (608535). RT-PCR detected ARPM1 expression in all tissues tested; the level of expression was lower than that of beta-actin.


▼ Mapping

Harata et al. (2001) mapped the ARPM1 gene in silico to chromosome 3q26.2.


▼ REFERENCES

  1. Harata, M., Nishimori, K., Hatta, S. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. Biochim. Biophys. Acta 1522: 130-133, 2001. [PubMed: 11750065, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 3/16/2004
Edit History:
mgross : 03/16/2004

* 608534

ACTIN-RELATED PROTEIN M1


Alternative titles; symbols

ARPM1


HGNC Approved Gene Symbol: ACTRT3

Cytogenetic location: 3q26.2   Genomic coordinates (GRCh38) : 3:169,766,921-169,769,561 (from NCBI)


TEXT

Cloning and Expression

By searching an EST database for actin-related proteins, Harata et al. (2001) identified ARPM1. The deduced 372-amino acid protein contains an actin-like ATP/ADP-binding pocket and 2 nuclear export signals. However, residues likely to be involved in actin-actin and actin-myosin (see 160730) contacts are not well conserved in ARPM1. ARPM1 shares 50% amino acid identity with beta-actin (102630) and 46% identity with ARPM2 (608535). RT-PCR detected ARPM1 expression in all tissues tested; the level of expression was lower than that of beta-actin.


Mapping

Harata et al. (2001) mapped the ARPM1 gene in silico to chromosome 3q26.2.


REFERENCES

  1. Harata, M., Nishimori, K., Hatta, S. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. Biochim. Biophys. Acta 1522: 130-133, 2001. [PubMed: 11750065] [Full Text: https://doi.org/10.1016/s0167-4781(01)00315-3]


Creation Date:
Patricia A. Hartz : 3/16/2004

Edit History:
mgross : 03/16/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024