Alternative titles; symbols
HGNC Approved Gene Symbol: ACTRT2
Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38) : 1:3,021,467-3,022,903 (from NCBI)
By searching an EST database for actin-related proteins, Harata et al. (2001) identified ARPM2. The deduced 377-amino acid protein contains an actin-like ATP/ADP-binding pocket and 2 nuclear export signals. However, residues likely to be involved in actin-actin and actin-myosin (see 160730) contacts are not well conserved in ARPM2. ARPM2 shares 48% amino acid identity with beta-actin (102630) and 46% identity with ARPM1 (608534). RT-PCR detected ARPM2 expression in all tissues tested; the level of expression was lower than that of beta-actin.
Heid et al. (2002) purified bovine Arpm2, which they designated Arpt2, from the calyx fraction of epididymal sperm heads. Using peptide sequences to search genomic and EST databases, they identified human ARPM2. The ARPM2 protein shares 75.5% amino acid identity with ARPT1 (300487). ARPT1 and ARPM2 contain several cysteine residues not found in beta-actin or other ARPs. Bovine Arpm2 showed an apparent molecular mass of about 40 kD.
Harata et al. (2001) mapped the ARPM1 gene in silico to chromosome 1p36.32.
Harata, M., Nishimori, K., Hatta, S. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. Biochim. Biophys. Acta 1522: 130-133, 2001. [PubMed: 11750065] [Full Text: https://doi.org/10.1016/s0167-4781(01)00315-3]
Heid, H. W., Figge, U., Winter, S., Kuhn, C., Zimbelmann, R., Franke, W. W. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. Exp. Cell Res. 279: 177-187, 2002. [PubMed: 12243744] [Full Text: https://doi.org/10.1006/excr.2002.5603]