Entry - *608618 - FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER C; FAM3C - OMIM

 
 
* 608618

FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER C; FAM3C


HGNC Approved Gene Symbol: FAM3C

Cytogenetic location: 7q31.31   Genomic coordinates (GRCh38) : 7:121,348,878-121,396,396 (from NCBI)


TEXT

▼ Cloning and Expression

By searching a database for sequences similar to FAM3A (300492), followed by RT-PCR of heart mRNA, Zhu et al. (2002) cloned FAM3C. The deduced 227-amino acid protein contains an N-terminal signal peptide. The authors predicted that FAM3C forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3C expression in almost all tissues tested.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the FAM3C gene to chromosome 7 (STS-H88599).

▼ REFERENCES

  1. Zhu, Y., Xu, G., Patel, A., McLaughlin, M. M., Silverman, C., Knecht, K. A., Sweitzer, S., Li, X., McDonnell, P., Mirabile, R., Zimmerman, D., Boyce, R., and 10 others. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80: 144-150, 2002. [PubMed: 12160727, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 4/28/2004
Edit History:
mgross : 04/28/2004

* 608618

FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER C; FAM3C


HGNC Approved Gene Symbol: FAM3C

Cytogenetic location: 7q31.31   Genomic coordinates (GRCh38) : 7:121,348,878-121,396,396 (from NCBI)


TEXT

Cloning and Expression

By searching a database for sequences similar to FAM3A (300492), followed by RT-PCR of heart mRNA, Zhu et al. (2002) cloned FAM3C. The deduced 227-amino acid protein contains an N-terminal signal peptide. The authors predicted that FAM3C forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3C expression in almost all tissues tested.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the FAM3C gene to chromosome 7 (STS-H88599).

REFERENCES

  1. Zhu, Y., Xu, G., Patel, A., McLaughlin, M. M., Silverman, C., Knecht, K. A., Sweitzer, S., Li, X., McDonnell, P., Mirabile, R., Zimmerman, D., Boyce, R., and 10 others. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80: 144-150, 2002. [PubMed: 12160727] [Full Text: https://doi.org/10.1006/geno.2002.6816]


Creation Date:
Patricia A. Hartz : 4/28/2004

Edit History:
mgross : 04/28/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024