Entry - *608619 - FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER D; FAM3D - OMIM

 
 
* 608619

FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER D; FAM3D


HGNC Approved Gene Symbol: FAM3D

Cytogenetic location: 3p14.2   Genomic coordinates (GRCh38) : 3:58,633,946-58,666,774 (from NCBI)


TEXT

▼ Cloning and Expression

By searching an EST database for sequences similar to FAM3A (300492), followed by RT-PCR of placenta mRNA, Zhu et al. (2002) cloned FAM3D. The deduced 224-amino acid protein contains an N-terminal signal peptide. The authors predicted that FAM3D forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3D expression at a high level in placenta and at a lower level in small intestine.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the FAM3D gene to chromosome 3 (RH80189).

▼ REFERENCES

  1. Zhu, Y., Xu, G., Patel, A., McLaughlin, M. M., Silverman, C., Knecht, K. A., Sweitzer, S., Li, X., McDonnell, P., Mirabile, R., Zimmerman, D., Boyce, R., and 10 others. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80: 144-150, 2002. [PubMed: 12160727, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 4/28/2004
Edit History:
mgross : 04/28/2004

* 608619

FAMILY WITH SEQUENCE SIMILARITY 3, MEMBER D; FAM3D


HGNC Approved Gene Symbol: FAM3D

Cytogenetic location: 3p14.2   Genomic coordinates (GRCh38) : 3:58,633,946-58,666,774 (from NCBI)


TEXT

Cloning and Expression

By searching an EST database for sequences similar to FAM3A (300492), followed by RT-PCR of placenta mRNA, Zhu et al. (2002) cloned FAM3D. The deduced 224-amino acid protein contains an N-terminal signal peptide. The authors predicted that FAM3D forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3D expression at a high level in placenta and at a lower level in small intestine.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the FAM3D gene to chromosome 3 (RH80189).

REFERENCES

  1. Zhu, Y., Xu, G., Patel, A., McLaughlin, M. M., Silverman, C., Knecht, K. A., Sweitzer, S., Li, X., McDonnell, P., Mirabile, R., Zimmerman, D., Boyce, R., and 10 others. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80: 144-150, 2002. [PubMed: 12160727] [Full Text: https://doi.org/10.1006/geno.2002.6816]


Creation Date:
Patricia A. Hartz : 4/28/2004

Edit History:
mgross : 04/28/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024