Entry - *608727 - DET1 PARTNER OF COP1 E3 UBIQUITIN LIGASE; DET1 - OMIM

 
 
* 608727

DET1 PARTNER OF COP1 E3 UBIQUITIN LIGASE; DET1


Alternative titles; symbols

DE-ETIOLATED 1, ARABIDOPSIS, HOMOLOG OF


HGNC Approved Gene Symbol: DET1

Cytogenetic location: 15q26.1   Genomic coordinates (GRCh38) : 15:88,501,919-88,546,703 (from NCBI)


TEXT

▼ Cloning and Expression

Wertz et al. (2004) reported that the human DET1 gene encodes a 550-amino acid protein (GenBank AK054603). Human DET expression was highest in ovary, some lymphoid organs, resting leukocytes, and certain cell lines.


▼ Gene Function

Wertz et al. (2004) reported that human DET1 promotes ubiquitination and degradation of the protooncogenic transcription factor c-Jun (165160) by assembling a multisubunit ubiquitin ligase containing DNA damage-binding protein-1 (DDB1; 600045), cullin 4A (CUL4A; 603137), regulator of cullins-1 (ROC1; 603814), and constitutively photomorphogenic-1 (COP1; 608067). Ablation of any subunit by RNA interference stabilized c-Jun and increased c-Jun-activated transcription. Wertz et al. (2004) concluded that their findings characterized a c-Jun ubiquitin ligase and define a specific function for DET1 in mammalian cells.


▼ REFERENCES

  1. Wertz, I. E., O'Rourke, K. M., Zhang, Z., Dornan, D., Arnott, D., Deshaies, R. J., Dixit, V. M. Human de-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303: 1371-1374, 2004. [PubMed: 14739464, related citations] [Full Text]


Creation Date:
Ada Hamosh : 6/11/2004
Edit History:
carol : 07/16/2020
alopez : 07/28/2006
terry : 7/24/2006
alopez : 6/11/2004

* 608727

DET1 PARTNER OF COP1 E3 UBIQUITIN LIGASE; DET1


Alternative titles; symbols

DE-ETIOLATED 1, ARABIDOPSIS, HOMOLOG OF


HGNC Approved Gene Symbol: DET1

Cytogenetic location: 15q26.1   Genomic coordinates (GRCh38) : 15:88,501,919-88,546,703 (from NCBI)


TEXT

Cloning and Expression

Wertz et al. (2004) reported that the human DET1 gene encodes a 550-amino acid protein (GenBank AK054603). Human DET expression was highest in ovary, some lymphoid organs, resting leukocytes, and certain cell lines.


Gene Function

Wertz et al. (2004) reported that human DET1 promotes ubiquitination and degradation of the protooncogenic transcription factor c-Jun (165160) by assembling a multisubunit ubiquitin ligase containing DNA damage-binding protein-1 (DDB1; 600045), cullin 4A (CUL4A; 603137), regulator of cullins-1 (ROC1; 603814), and constitutively photomorphogenic-1 (COP1; 608067). Ablation of any subunit by RNA interference stabilized c-Jun and increased c-Jun-activated transcription. Wertz et al. (2004) concluded that their findings characterized a c-Jun ubiquitin ligase and define a specific function for DET1 in mammalian cells.


REFERENCES

  1. Wertz, I. E., O'Rourke, K. M., Zhang, Z., Dornan, D., Arnott, D., Deshaies, R. J., Dixit, V. M. Human de-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303: 1371-1374, 2004. [PubMed: 14739464] [Full Text: https://doi.org/10.1126/science.1093549]


Creation Date:
Ada Hamosh : 6/11/2004

Edit History:
carol : 07/16/2020
alopez : 07/28/2006
terry : 7/24/2006
alopez : 6/11/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024