Alternative titles; symbols
HGNC Approved Gene Symbol: SLC39A10
Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38) : 2:195,613,029-195,737,700 (from NCBI)
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).
By sequencing clones obtained from a size-fractionated adult brain cDNA library, Nagase et al. (1999) cloned SLC39A10, which they designated KIAA1265. The deduced 835-amino acid protein shares 36% identity with LIV1 (SLC39A6; 608731). RT-PCR ELISA detected SLC39A10 expression in all tissues and specific brain regions examined. Highest expression was in spinal cord, and lowest expression was in pancreas and spleen.
By searching a database for sequences similar to a unique motif within LIV1, Taylor and Nicholson (2003) identified SLC39A10, which they designated LZT-Hs2. SLC39A10 contains a long N terminus, followed by 8 putative transmembrane domains and a short C terminus. It also has a high histidine content, including a motif similar to the catalytic zinc-binding site of matrix metalloproteases. SLC39A10 was expressed on the plasma membrane of transfected Chinese hamster ovary cells. It colocalized with F-actin and concentrated on lamellipodiae in a manner similar to membrane-type matrix metalloproteases.
By radiation hybrid analysis, Nagase et al. (1999) mapped the SLC39A10 gene to chromosome 2.
Nagase, T., Ishikawa, K., Kikuno, R., Hirosawa, M., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999. [PubMed: 10574462] [Full Text: https://doi.org/10.1093/dnares/6.5.337]
Taylor, K. M., Nicholson, R. I. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta 1611: 16-30, 2003. [PubMed: 12659941] [Full Text: https://doi.org/10.1016/s0005-2736(03)00048-8]