Entry - *608891 - ODD-SKIPPED-RELATED TRANSCRIPTION FACTOR 1; OSR1 - OMIM

 
 
* 608891

ODD-SKIPPED-RELATED TRANSCRIPTION FACTOR 1; OSR1


Alternative titles; symbols

ODD-SKIPPED, DROSOPHILA, HOMOLOG OF; ODD


HGNC Approved Gene Symbol: OSR1

Cytogenetic location: 2p24.1   Genomic coordinates (GRCh38) : 2:19,344,874-19,358,623 (from NCBI)


TEXT

▼ Cloning and Expression

By performing BLAST analysis of human genomic sequence with sequences of Drosophila zinc finger proteins 'odd-skipped,' 'odd-skipped related,' or 'bowl' as queries, Katoh (2002) identified partial sequence of the human OSR1 gene; RT-PCR amplification obtained the complete cDNA sequence. The OSR1 gene encodes a predicted 266-amino acid protein containing 3 C2H2-type zinc fingers, a tyrosine phosphorylation site, and several putative PXXP SH3 binding motifs. OSR1 and OSR2 (611297) proteins share 63.6% sequence identity. Northern blot analysis showed expression of a 2.3-kb OSR1 transcript in adult colon, small intestine, prostate, testis, and fetal lung. RT-PCR analysis showed OSR1 upregulation in 1 of 7 pancreatic cancer cell lines and weak expression in 2 of 7 gastric, 5 of 7 pancreatic, and 1 of 12 esophageal cancer cell lines. OSR1 expression was upregulated in 5 and downregulated in 2 of 10 primary gastric cancers.


▼ Gene Structure

By cDNA and human genomic sequence alignment, Katoh (2002) showed that the OSR1 gene contains 3 exons.


▼ Mapping

By genomic sequence analysis, Katoh (2002) mapped the OSR1 gene to chromosome 2p24.


▼ REFERENCES

  1. Katoh, M. Molecular cloning and characterization of OSR1 on human chromosome 2p24. Int. J. Molec. Med. 10: 221-225, 2002. [PubMed: 12119563, related citations]


Creation Date:
Laura L. Baxter : 8/31/2004
Edit History:
carol : 01/11/2022
wwang : 08/03/2007
alopez : 8/31/2004

* 608891

ODD-SKIPPED-RELATED TRANSCRIPTION FACTOR 1; OSR1


Alternative titles; symbols

ODD-SKIPPED, DROSOPHILA, HOMOLOG OF; ODD


HGNC Approved Gene Symbol: OSR1

Cytogenetic location: 2p24.1   Genomic coordinates (GRCh38) : 2:19,344,874-19,358,623 (from NCBI)


TEXT

Cloning and Expression

By performing BLAST analysis of human genomic sequence with sequences of Drosophila zinc finger proteins 'odd-skipped,' 'odd-skipped related,' or 'bowl' as queries, Katoh (2002) identified partial sequence of the human OSR1 gene; RT-PCR amplification obtained the complete cDNA sequence. The OSR1 gene encodes a predicted 266-amino acid protein containing 3 C2H2-type zinc fingers, a tyrosine phosphorylation site, and several putative PXXP SH3 binding motifs. OSR1 and OSR2 (611297) proteins share 63.6% sequence identity. Northern blot analysis showed expression of a 2.3-kb OSR1 transcript in adult colon, small intestine, prostate, testis, and fetal lung. RT-PCR analysis showed OSR1 upregulation in 1 of 7 pancreatic cancer cell lines and weak expression in 2 of 7 gastric, 5 of 7 pancreatic, and 1 of 12 esophageal cancer cell lines. OSR1 expression was upregulated in 5 and downregulated in 2 of 10 primary gastric cancers.


Gene Structure

By cDNA and human genomic sequence alignment, Katoh (2002) showed that the OSR1 gene contains 3 exons.


Mapping

By genomic sequence analysis, Katoh (2002) mapped the OSR1 gene to chromosome 2p24.


REFERENCES

  1. Katoh, M. Molecular cloning and characterization of OSR1 on human chromosome 2p24. Int. J. Molec. Med. 10: 221-225, 2002. [PubMed: 12119563]


Creation Date:
Laura L. Baxter : 8/31/2004

Edit History:
carol : 01/11/2022
wwang : 08/03/2007
alopez : 8/31/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024