Alternative titles; symbols
HGNC Approved Gene Symbol: GPR142
Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38) : 17:74,367,506-74,372,600 (from NCBI)
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).
By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR142. The deduced 462-amino acid protein assumes a classic 7-transmembrane (TM) topology and has a DRY motif in the intracellular side of TM3. It also contains a NPxxY motif. GPR142 shares 68% amino acid identity with mouse Gpr142.
By bioinformatic analysis, Matsuo et al. (2005) identified human GPR142, which they termed GPRG1B. The predicted 374-amino acid protein has 7 transmembrane domains and shares 44% identity with human GPR139 (618448). Quantitative PCR analysis revealed that human GPRG1B transcripts were widely distributed in peripheral tissues and central nervous system (CNS). Strongest expression was in thyroid gland, with moderate expression in corpus callosum and cerebellum within CNS, and in spleen, small intestine, and pancreas among peripheral tissues.
Fredriksson et al. (2003) determined that the GPR142 gene contains 4 coding exons. The mouse Gpr142 gene contains 3 coding exons.
Matsuo et al. (2005) determined that the GPR142 gene contains 3 exons.
By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR142 gene to chromosome 17q25.1. They mapped the mouse Gpr142 gene to chromosome 11.
Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098] [Full Text: https://doi.org/10.1016/s0014-5793(03)01196-7]
Matsuo, A., Matsumoto, S., Nagano, M., Masumoto, K., Takasaki, J., Matsumoto, M., Kobori, M., Katoh, Ml, Shigeyoshi, Y. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. Biochem. Biophys. Res. Commun. 331: 363-369, 2005. [PubMed: 15845401] [Full Text: https://doi.org/10.1016/j.bbrc.2005.03.174]