HGNC Approved Gene Symbol: SCAND2P
Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38) : 15:84,631,460-84,642,463 (from NCBI)
By searching ESTs for sequences similar to EGLN1 (606425), Dupuy et al. (2000) cloned SCAND2. The deduced 306-amino acid protein has a calculated molecular mass of 34 kD. SCAND2 contains an N-terminal SCAN domain and a C terminus encoded by an EGLN1-homologous sequence. The authors determined that SCAND2 is a fusion gene, resulting from the disruption of an ancestral SCAN zinc finger gene by retropositioning of a EGLN1 copy from chromosome 1, followed by exon shuffling. The coding sequence derived from EGLN1 is out-of-frame relative to the original EGLN1 protein product. EST database analysis revealed SCAND2 splice variants that differed in their 3-prime UTR. Although SCAND2 contains a complete SCAN domain commonly found in zinc finger proteins, Dupuy et al. (2002) determined that SCAND2 is not a zinc finger protein due to its long C terminus derived from the EGLN1 gene.
Dupuy et al. (2000) determined that the SCAND2 gene contains 7 exons and spans about 12 kb. Only exons 1 and 2 are coding exons.
By FISH, Dupuy et al. (2000) mapped the SCAND2 gene to chromosome 15q25-q26.
Dupuy, D., Aubert, I., Duperat, V. G., Petit, J., Taine, L., Stef, M., Bloch, B., Arveiler, B. Mapping, characterization, and expression analysis of the SM-20 human homologue, C1orf12, and identification of a novel related gene, SCAND2. Genomics 69: 348-354, 2000. [PubMed: 11056053] [Full Text: https://doi.org/10.1006/geno.2000.6343]
Dupuy, D., Duperat, V. G., Arveiler, B. SCAN domain-containing 2 gene (SCAND2) is a novel nuclear protein derived from the zinc finger family by exon shuffling. Gene 289: 1-6, 2002. [PubMed: 12036577] [Full Text: https://doi.org/10.1016/s0378-1119(02)00543-7]