HGNC Approved Gene Symbol: PDIK1L
Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38) : 1:26,111,162-26,125,555 (from NCBI)
Guo et al. (2003) cloned PDIK1L from a fetal brain cDNA library as part of a high throughput DNA sequencing analysis. The deduced 341-amino acid PDIK1L protein shares 69% and 27% sequence identity with CLIK1 (STK35; 609370), which interacts with PDZ-LIM proteins, and mouse serine/threonine protein kinase-33 (STK33; 607670), respectively. PDIK1L contains a predicted serine/threonine protein kinase catalytic domain, including a conserved active site signature and a protein kinase ATP-binding region. Because bioinformatics analysis suggested that the putative kinase may interact with PDZ and LIM domain proteins, Guo et al. (2003) named the protein PDLIM1-interacting kinase-1-like. By PCR analysis, Guo et al. (2003) detected PDIK1L expression in human liver, kidney, pancreas, spleen, thymus, and prostate, with lower expression detected in placenta, heart, and brain. Immunofluorescence studies localized PDIK1L to the nucleus in COS-7 cells.
Guo et al. (2003) determined that the PDIK1L gene contains 4 exons and spans 13.7 kb.
By genomic sequence analysis, Guo et al. (2003) mapped the PDIK1L gene to chromosome 1p35.3.
Guo, L., Ji, C., Gu, S., Ying, K., Cheng, H., Ni, X., Liu, J., Xie, Y., Mao, Y. Molecular cloning and characterization of a novel human kinase gene, PDIK1L. J. Genet. 82: 27-32, 2003. [PubMed: 14631099] [Full Text: https://doi.org/10.1007/BF02715878]