Alternative titles; symbols
HGNC Approved Gene Symbol: UTP18
Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38) : 17:51,260,546-51,297,933 (from NCBI)
UTP18 is a nucleolar protein that localizes predominantly to the dense fibrillar component, which is associated with early ribosomal RNA (rRNA)-processing events, and to the granular component, which is associated with late rRNA-processing events and assembly of ribosomal particles (Wada et al., 2014).
By database analysis, Bernstein et al. (2004) identified UTP18, the human ortholog of yeast Utp18. Yeast Utp18 is a component of a ribonucleoprotein required for biogenesis of the 18S rRNA.
By PCR of human prostate and testis cDNA libraries, Wada et al. (2014) cloned UTP18. Fluorescence-tagged UTP18 localized throughout nucleoli in transfected HeLa cells, predominantly to the dense fibrillar component and granular component. A portion also localized to nucleoplasm. Fluorescence recovery after photobleaching showed that UTP18 associated stably with nucleoli, and association of UTP18 with nucleoli was not affected by inhibition of transcription.
Hartz (2009) mapped the UTP18 gene to chromosome 17q21.33 based on an alignment of the UTP18 sequence (GenBank AF151806) with the genomic sequence (build 36.1).
Bernstein, K. A., Gallagher, J. E. G., Mitchell, B. M., Granneman, S., Baserga, S. J. The small-subunit processome is a ribosome assembly intermediate. Eukaryotic Cell 3: 1619-1626, 2004. [PubMed: 15590835] [Full Text: https://doi.org/10.1128/EC.3.6.1619-1626.2004]
Hartz, P. A. Personal Communication. Baltimore, Md. 5/27/2009.
Wada, K., Sato, M., Araki, N., Kumeta, M., Hirai, Y., Takeyasu, K., Furukawa, K., Horigome, T. Dynamics of WD-repeat containing proteins in SSU processome components. Biochem. Cell Biol. 92: 191-199, 2014. [PubMed: 24754225] [Full Text: https://doi.org/10.1139/bcb-2014-0007]