Phenotypes associated with the disease familial adenomatous polyposis 3 (OMIM:616415):
- Adenomatous colonic polyposis (HP:0005227): Presence of multiple adenomatous polyps in the colon. Evidence: PCS. Frequency: 7/7. (PMID:25938944)
- Pancreatic adenocarcinoma (HP:0006725): The presence of an adenocarcinoma of the pancreas. Evidence: PCS. Frequency: 1/7. (PMID:25938944)
- Breast carcinoma (HP:0003002): The presence of a carcinoma of the breast. Evidence: PCS. Frequency: 1/3. (PMID:25938944)
- Colon cancer (HP:0003003). Evidence: PCS. Frequency: 4/7. (PMID:25938944)
- Basal cell carcinoma (HP:0002671): The presence of a basal cell carcinoma of the skin. Evidence: PCS. Frequency: 2/7. (PMID:25938944)
- Adult onset (HP:0003581): Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later. Evidence: PCS. Frequency: 7/7. (PMID:25938944)
- Meningioma (HP:0002858): The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater. Evidence: PCS. Frequency: 1/7. (PMID:25938944)
- Duodenal adenocarcinoma (HP:0006771): A malignant epithelial tumor with a glandular organization that originates in the duodenum. Evidence: PCS. Frequency: 1/7. (PMID:25938944)
- Autosomal recessive inheritance (HP:0000007): A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele). Evidence: PCS. (PMID:25938944)
- Prostate cancer (HP:0012125): A cancer of the prostate. Evidence: PCS. Frequency: 1/4. (PMID:25938944)
- Endometrial carcinoma (HP:0012114): A carcinoma of the endometrium, the mucous lining of the uterus. Evidence: PCS. Frequency: 2/3. (PMID:25938944)
- Bladder neoplasm (HP:0009725): The presence of a neoplasm of the urinary bladder. Evidence: TAS. (OMIM:616415)