- Vesicoureteral reflux (HP:0000076): Abnormal (retrograde) movement of urine from the bladder into ureters or kidneys related to inadequacy of the valvular mechanism at the ureterovesicular junction or other causes. Evidence: PCS. Frequency: 5/10. (PMID:31051115)
- Congenital posterior urethral valve (HP:0010957): A developmental defect resulting in an obstructing membrane in the posterior male urethra. Evidence: PCS. Frequency: 3/10. (PMID:31051115)
- Urinary incontinence (HP:0000020): Loss of the ability to control the urinary bladder leading to involuntary urination. Evidence: PCS. Frequency: 2/10. (PMID:31051115)
- Urethral stenosis (HP:0008661): Abnormal narrowing of the urethra. Evidence: PCS. Frequency: 4/10. (PMID:31051115)
- Pollakisuria (HP:0100515): Increased frequency of urination. Evidence: PCS. Frequency: 2/10. (PMID:31051115)
- Autosomal dominant inheritance (HP:0000006): A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. Evidence: PCS. (PMID:31051115)
These phenotypes are associated with the disease lower urinary tract obstruction, congenital (OMIM:618612).